Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma
نویسندگان
چکیده
منابع مشابه
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma.
When it escapes early detection, malignant melanoma becomes a highly lethal and treatment-refractory cancer. Melastatin is greatly downregulated in metastatic melanomas and is widely believed to function as a melanoma tumor suppressor. Here we report that tumor suppressive activity is not mediated by melastatin but instead by a microRNA (miR-211) hosted within an intron of melastatin. Increasin...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2010
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2010.11.020